Systemic mastocytosis affects more than one part of the body and is more common in adults. The signs and symptoms of mastocytosis vary based on which parts of the body are affected. Mycophenolate and plaquenil Hydroxychloroquine sulfate 2 I have been on Plaquenil for 4 years now, with the initial side effects a little stomach upset-take w/food having worn off in about 2 weeks, without that horrible pain or need for a dose increase. The only thing I need to do with Plaquenil is an eye exam every 6 months.check for changes in vision. Mast cell activation syndrome MCAS, is an immunological condition in which mast cells mistakenly release too many chemical mediators, resulting in several chronic symptoms involving the skin, gastrointestinal tract, heart, respiratory, and neurologic systems. Histiocytosis is a general name for a group of disorders or "syndromes" that involve an abnormal increase in the number of specialized white blood cells that are called histiocytes. Recently, new knowledge about this family of diseases has led experts to develop a new classification. Many people affected by mastocytosis, especially systemic mastocytosis, also have symptoms of anxiety and depression. Signs and symptoms of mastocytosis are more likely to occur after a “trigger” such as a change in temperature, certain medications, emotional stress, or irritation of the skin. Plaquenil and mastocytosis Final Diagnosis -- Case 867 - UPMC, Mast cell activation syndrome Genetic and Rare Diseases. Blood monitoring hydroxychloroquine Mastocytosis causes a wide range of symptoms, which can vary depending on the type of mastocytosis you have. Cutaneous mastocytosis. Skin lesions are a characteristic of cutaneous mastocytosis. Types of lesions known to occur in cutaneous mastocytosis include small areas of skin that change colour macules small firm, raised bumps papules Mastocytosis - Symptoms - NHS. Histiocytosis MedlinePlus Medical Encyclopedia. Mastocytosis Genetic and Rare Diseases Information Center.. Immune modulators Humira, Enbrel, Plaquenil Antiarrhythmics propranolol, metoprolol, Cardizem, Norvasc. mastocytosis or overactive mast cells MCAS or mast cell activation syndrome. These conditions may be helped with the reduction of histamine intake, but they are more severe and can interfere with daily life, requiring treatments. Plaquenil/mepacrine and NSAID medication including ibuprofen and diclofenac. read more about this here-Medication to lower histamine or mast cells in the body can help for those who flush and burn antihistamines, mastocytosis medication including inorial and zaditine, anti asthma meds including montelukast. Note This document contains side effect information about azathioprine. Some of the dosage forms listed on this page may not apply to the brand name Imuran. In Summary. Common side effects of Imuran include infection, leukopenia, and vomiting. See below for a comprehensive list of adverse effects.