Nevertheless, retinopathy begins to appear with long-term use, and retinopathy is serious insofar as there is no known treatment. It can progress for a year or more after stopping the drug and, if not recognized early (at the point of screening), it can lead to functional blindness. How long has plaquenil been on the market Hydroxychloroquine and platelets Aug 29, 2014 Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. On the other hand, visible bull’s-eye retinopathy. Spectral-domain optical coherence tomography demonstrating advanced hydroxychloroquine retinopathy with parafoveal loss of the external limiting membrane, disruption of the outer ellipsoid zone, thinning of the outer nuclear layer and disruption to the underlying retinal pigment. Nov 01, 2007 Figure 2a. Color photograph OD revealing a classic Bull's eye lesion in a patient on hydroxychloroquine therapy for rheumatoid arthritis. Figure 2b. FA highlights the area of pigment loss. Thioridazine. Thioridazine is a phenothiazine antipsychotic agent known to cause a pigmentary retinopathy. Hydroxychloroquine, sold under the brand name Plaquenil (Sanofi-Aventis), is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. The classic clinical picture of HCQ toxicity is a “bull’s eye” maculopathy (see Figure 1)—but as I’ll later note, this is a late finding. Plaquenil bull's eye retinopathy Bull's-eye maculopathy due to hydroxychloroquine toxicity, Multimodal Imaging in Plaquenil Toxicity Plaquenil and chest painDoes hydroxychloroquine help with psoriatic arthritisChloroquine cathepsinChagas disease is treated with chloroquine t fPlaquenil used for lyme disease Definition Bull’s eye maculopathy describes a number of different conditions in which there is a ring of pale-looking damage around a darker area of the macula. The macula can often appear to have circular bands of different shades of pink and orange. Age of onset and severity of sight loss varies, and it can be Bull's Eye Maculopathy – Causes, Complications, and.. Retinal Physician - Retinal Toxicities Caused by Systemic.. Plaquenil Toxicity. Autofluorescence can detect even earlier retinopathy before the visual loss. Treatment and medications. There is no good way to treat inherited genetic eye conditions that cause Bull’s Eye Maculopathy. Usually, there is also no good way to stop the sight loss that often occurs along with Bull’s Eye Maculopathy. Taking Hydroxychloroquine develop toxicity2 It’s rare for side effects to occur with Plaquenil if the medication is dosed properly Side effects Blurred vision, bull’s eye maculopathy, scotoma, vortex keratopathy, headache, accommodative dysfunction, whitening of eyelashes, phototoxicity3 Retinal photograph showing classic “bull’s eye” retinopathy of hydroxychloroquine toxicity, which represents atrophy of the retinal pigment epithelium. This is a relatively late change, and good screening can detect toxicity before any bull’s eye is visible.