Please review the following URL and make sure that it is spelled correctly. Plaquenil (hydroxychloroquine) is a Disease Modifying Anti-Rheumatic Drug (DMARD) that is widely used to reduce inflammation (pain and swelling) in the treatment of many types of arthritis and lupus. Do chloroquine cause splenomegaly Hydroxychloroquine dental side effects Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARDregulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Feeling sick on plaquenil deleted_user 10/15/2011 I started taking plaquenil 11 days ago. 200mg twice a day when I was diagnosed with MCTD and Lupus I had posted before that I only had MCTD, but after going over my Dr's paperwork, I do indeed have both- which my Doc failed to inform me of. All blood work came back "normal", lupus is in remission/ inactive. Yay! Dr stopped Hydroxychloroquine plaquenil yesterday fearing it is now doing more harm than good. Over all I do feel it may have caused increased anxiety and depression and irritability.however lupus alone can trigger those symptoms I'm sure. When Plaquenil works, most patients start to feel improvement after 8-12 weeks. When patients start Plaquenil, doctors usually have them try it for 3 months before they assess the patient to determine if it is working. Plaquenil is also known as a treatment for malaria, a blood-borne parasite spread by mosquitoes in many tropical and sub-tropical environments. The usual dose is between one and two tablets per day (200 to 400 mg per day). Plaquenil and feeling sick Plaquenil and dizziness? Updated, Feeling sick on plaquenil DailyStrength Hydroxychloroquine prednisone adverse effectsTrental and plaquenil together Nov 12, 2009 Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. What is the correct way to discontinue use of plaquenil?. PLAQUENIL Side Effects, Reviews by Patients -. PLAQUENIL 200MG FILM-COATED TABLETS. I have just restarted hydroxychloroquine one a day due to increase to two in two days time. I was on this alone for some years about twenty years ago and can't remember feeling sick all the time. This time I'm adding it to methotrexate which already makes me feel sick, so perhaps this is the problem. Obviously I asked to go back on Plaquenil as it worked so well the first time. But the motion sick feeling is back. It only lasts about half an hour right now but each bout is longer than the last one. I don't want to give up the plaq. Long story short, Sed rate and RA factor were elevated. Because I was feeling sooo sick, my GP put me on prednisone and referred me to a Rheumatologist. After 5 to 6 days I felt 100% better. In fact, I hadn't felt that good in years. My Rheumy, however, prescribed Plaquenil and Sulfasalazine and told me decrease the prednisone.