It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Hydroxychloroquine and t cells Plaquenil dry eyes Drugs that inhibit CYP3A4 enzymes may increase plasma levels of hydroxychloroquine. Proton pump inhibitors may antagonize the immunomodulating effects of hydroxychloroquine. 7. Additional known interactions between hydroxychloroquine and coadministered drugs may be described in the FDA-approved Full Prescribing Information for Plaquenil. 9. Hydroxychloroquine is a prescription drug. It comes as an oral tablet. Hydroxychloroquine is available as the brand-name drug Plaquenil. It’s also available in a generic version. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Hydroxychloroquine ppt Antimalarial drugs, Hydroxychloroquine Side Effects, Dosage, Uses, and More Chloroquine inhibitor Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Chloroquine and Hydroxychloroquine Toxicity Practice.. Chloroquine - Wikipedia. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. Maximum dose 300 mg base/dose 500 mg salt/dose -For prophylaxis only in areas with chloroquine-sensitive malaria. -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly same day each week while in malarious areas and for 4 weeks after leaving such areas. Usual Pediatric Dose for Malaria. Disease-Modifying Antirheumatic Drugs DMARD Hydroxychloroquine sulfate Plaquenil, generic Comes in tablet only. Antimalarial drugs are commonly used to treat rheumatoid arthritis and can help improve the skin lesions of lupus, and can hold off disease recurrence and prevent organ damage. Serious side effects for antimalarial drugs are rare.