Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. What is hydroxychloroquine side effects Chloroquine tablet brand name Been off of plaquenil for about 5 months and I can tell difference of my sleep. I sleep more hours during those periods I stop taking plaquenil. Now, that I am back taking plaquenil I could hardly sleep. I think I just sleep 2 hours or less or a little bit more than 2 hours each night. Does anyone. I've been on plaquenil since 2011 and I haven't had any issues like that with it. Not even any unusual dreams. I do get sleep paralysis on very rare occasions, but that started well before the plaquenil, and I've only had one incident since. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil sleep problems Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis., Hydroxychloroquine/plaquenil and sleepwalking lupus Plaquenil tylenolUsing hydroxychloroquine and leflunomide together Plaquenil is very effective for the symptoms of achiness and fatigue. However, there might be a price to pay in terms of retinal toxicity especially after taking it for as long as you have. Given that the alopecia had developed while you were on the plaquenil, it's not clear that going back on it will help that symptom much. PLAQUENIL To Take or Not To Take?" Lupus Community.. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil - Lupus. Plaquenil and Eye Problems. Plaquenil can cause serious vision problems that aren't always reversible. Tell your doctor immediately if you notice any changes in vision or if you've ever had vision. Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay. If rheumatoid arthritis has you tossing and turning at night, you’re not alone. While the exact percentage of RA patients who experience sleep problems is hard to nail down, more than 80% of people with RA report fatigue as part of their symptoms.