Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Plaquenil sulfate Acid reflux and plaquenil Roquine Plaquenil; Sanofi, and generic formulations. The effects of toxic medications can be detected and quantified using ERG. Which type of ERG to apply depends on the mechanism and site of retinal toxic-ity. Identifying retinal toxicity due to chloroquine or hydroxychloroquine is a pertinent application of mfERG. SIGNS OF TOXICITY Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. MfERG changes correlate with both structural SD-OCT and functional HVF 10-2 findings in detecting HCQ retinopathy 89, 90. Maturi et al. noted that mfERG changes were associated with a cumulative dose of 500 g and 5 years use and could be classified into four patterns paracentral loss, foveal loss, peripheral loss and generalized loss. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Mferg plaquenil Multifocal ERG in Practice, Plaquenil Oral Uses, Side Effects, Interactions. Risk of plaquenil retinopathyHow does plaquenil work on the immune systemChloroquine buy on lineHow does plaquenil treat arthritis A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. Hydroxychloroquine Plaquenil Toxicity and.. Hydroxychloroquine-related retinal toxicity Rheumatology.. Early Plaquenil Toxicity Detected without Bull’s Eye.. What does Plaquenil/hydroxychloroquine do to your eyes? The retina is the film in the back of your eyes. CQ and HCQ can both cause maculopathy or retinopathy. Prior to modern diagnostic techniques, your eye doctor was looking for bull’s eye maculopathy with a dilated exam. The Diopsys® mfERG vision test is a painless, safe, non-invasive way for your eye care provider to objectively measure the function of your retina – the light-sensitive layer at the back of your eye. When light from an image enters your eye, it is turned into electrical energy by cells in the retina. Multi-focal Electroretinography mfERG may be considered medically necessary for detecting chloroquine Aralen and hydroxychloroquine Plaquenil toxicity. mfERG is considered experimental, investigational and/or unproven for all other indications, including but not limited to the diagnosis and evaluation of glaucoma and the prediction of.