Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Hydroxychloroquine cancer stem cells Does plaquenil cause bile malabsorption Visual prolem with plaquenil Plaquenil toxicity autofluorescence The therapy would use a combination of two FDA Food and Drug Administration approved drugs that are currently being used for other types of cancer – namely trametinib and hydroxychloroquine. Trametinib is a cancer treatment that specifically targets the MEK1 and MEK2 proteins within the cancer cell. MEK1 and MEK2 are part of a pathway called MAPK, which is directed by KRAS. MEK1 and MEK2 are part of a pathway called MAPK, which is directed by KRAS. Abstract. Pancreatic ductal adenocarcinoma PDAC is a recalcitrant disease responsible for ~43,000 deaths in the USA in 2017. Despite an advanced understanding of the genetics, biochemistry and biology of pancreatic cancer, there is no effective pathway-targeted therapy for PDAC such that the standard of care treatment for most patients remains conventional cytotoxic chemotherapy. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Trametinib hydroxychloroquine pancreatic cancer Taking a Different Approach to Pancreatic Cancer Treatment., Combination Delivers Dual Punch to Pancreatic Cell Growth. Plaquenil and bone lossChloroquine and doxycyclineDoes chloroquine interact with vitamins Mekinist trametinib is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Mekinist is used alone or in combination with another medicine called dabrafenib Tafinlar to treat certain types of cancer in people who have a "BRAF" gene mutation. Mekinist Uses, Dosage, Side Effects & Warnings -. Abstract LB-254 Combined inhibition of. - Cancer Research. Utah researchers identify potential treatment for.. The Pancreatic Cancer Action Network PanCAN is dedicated to fighting the world’s toughest cancer. In our urgent mission to save lives, we attack pancreatic cancer on all fronts research, clinical initiatives, patient services and advocacy. Our effort is amplified by a nationwide network of grassroots support. FDA grants regular approval to dabrafenib and trametinib combination for metastatic NSCLC with BRAF V600E mutation. NGS test to detect multiple gene mutations for lung cancer in a single test. The findings presented today focused on advanced pancreatic cancer patients who enrolled in XCELSIOR and were treated with a MEK inhibitor, trametinib, in combination with an autophagy inhibitor, hydroxychloroquine, a generic medication approved by the U. S. Food and Drug Administration FDA for treatment of malaria, as part of their clinical cancer care.