Had symtoms of malar rash, joint pain especially in hands, fatigue , dry eyes and dry skin . Had a biopsy of skin and confirmed cutaneous lupus. I was put on Plaquenil and for the past 8 years I have been fine with it . Now this year I have been having things pop up that are related to a low immune system. Using hydroxychloroquine and leflunomide together Plaquenil derived from What does hydroxychloroquine sulfate do Plaquenil short term side effects Hydroxychloroquine This antimalarial drug has immunomodulatory properties and is used in a variety of autoimmune diseases. It is relatively well tolerated at the commonly used dosages of 200–400 mg/day. The types of drugs that have been used to treat lupus include NSAIDs, corticosteroids and other immune system suppressing drugs, hydroxychloroquine, and the newest lupus drug, Benlysta. Lupus. My LLMD just precribed Plaquenil to me. so far so good tho I am concerned about the Vision issues with this medication but from everything I read its very rare to have Vision problems and nothing I read said that it was an Immune suppressant. Does anybody have any input concerning taking Plaquenil for long term therapy ? Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack . I tried to only take 100 mg to see if it would make a difference but I started with terrible joint pain and fatigue so I am back on the 200 mg a day. Hydroxychloroquine immune suppressant Do either hydroxychol/Plaquenil put you at risk for., Lupus Medications and Treatments Is chloroquine phosphate malaria medicationRa mediciane hydroxychloroquinePlaquenil guidelines aao 2016How long does plaquenil stay in yoursystemDoxycycline plaquenil lyme Hydroxychloroquine Plaquenil is an antimalarial drug that also has anti-inflammatory qualities and is used to treat certain autoimmune diseases, including rheumatoid arthritis and Sjögren’s disease. Hydroxychloroquine is take orally by mouth. Common side effects include vomiting, headache, changes in vision, and muscle weakness. Immunosuppressants The Myositis Association. Is Plaquenil an immumo-suppressant?. Hydroxychloroquine and the immune system Hi everyone.. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. Yes Rituximab rituxin is a monoclonal antibody to cd20 an antigen located on lymphocytes. One consequence of using this drug is a drop in lymphocyte numbers bad cells and good cells. This decline lowers the effectiveness of the immune system for a period of time. Anti-DNA antibodies exert their pathogenic effects through deposition as immune complexes in the kidney or through the recognition of cross-reactive antigens in the kidney, while in situ deposition of an immune complex composed of DNA, anti-DNA antibody and IgG in the renal tissue leads to the activation of the complement system and causes a.