Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hydroxychloroquine with all of your drugs and health problems. Hydroxychloroquine surfactant protein c deficiency Chloroquine and doxycycline Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Preclinical studies indicate autophagy inhibition with hydroxychloroquine HCQ can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose MTD and efficacy of HCQ in combination with radiation therapy RT and temozolomide TMZ for newly diagnosed glioblastoma GB. Trade Name Plaquenil. ® How is this drug used? Plaquenil is used to for the treatment of rheumatoid arthritis RA, some symptoms of lupus, childhood arthritis JIA, and other autoimmune is also used for the prevention or treatment of malaria caused by mosquito bites. What is the mechanism of action? For all uses of hydroxychloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Plaquenil and radiation Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., A phase I/II trial of hydroxychloroquine in conjunction. Hydroxychloroquine plaquenil and pregnancyChloroquine dose in rheumatoid arthritisChloroquine solubility dmso Radiation therapy uses high-energy x-rays to kill tumor cells. Giving hydroxychloroquine together with temozolomide and radiation therapy may kill more tumor cells. PURPOSE This phase I/II trial is studying the side effects and best dose of hydroxychloroquine when given together with radiation therapy and temozolomide and to see how well they work in treating patients with newly diagnosed glioblastoma multiforme. Hydroxychloroquine, Radiation, and Temozolomide Treating.. Plaquenil. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have had any eye changes or changes in eyesight due to hydroxychloroquine or drugs like this one. If you have psoriasis. Radiation Treatment for Cancer Lupus, as well as other systemic autoimmune illnesses such as rheumatoid arthritis or scleroderma, are chronic, lifelong diseases. Although not unusually susceptible to develop cancer, some patients with rheumatic diseases, in natural course of events, do develop other illnesses such as breast cancer. NEW YORK Reuters Health - The antimalarial drug hydroxychloroquine overcomes breast cancer resistance to tamoxifen, according to preclinical studies of estrogen receptor-positive ER+ mammary tumors.