Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Benefits of plaquenil for lupus How often to take aralen Plaquenil malaria treatment Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. 1 It is taken by mouth. In SLE patients the cytokine levels were measured just before and three months after starting chloroquine treatment at a dose of 125 mg twice daily. Although the majority of SLE patients had a low systemic lupus activity measure SLAM index, the levels of IL-6, IL-18 and TNF-alpha were significantly higher than in the control group. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine use in sle Hydroxychloroquine Uses, Dosage & Side Effects -, Hydroxychloroquine - Wikipedia Macrobid and hydroxy chloroquine interactions Early use of hydroxychloroquine prevents damage accrual in systemic lupus erythematosus. Birmingham, AL - Starting the antimalarial drug hydroxychloroquine HCQ Plaquenil early on in the disease process may help prevent damage accrual in patients with systemic lupus erythematosus SLE 1. Hydroxychloroquine in SLE. Chloroquine treatment influences proinflammatory cytokine.. Chloroquine Oral Uses, Side Effects, Interactions.. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Initial dose for the treatment of SLE, 400mg×2/day, is about the dose used in one of the studies above. Maintenance dose would keep the serum concentration constant. Assuming HCQ is effective, it would most definitely be protective in doses used in SLE patients. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided.