If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Tylenol and plaquenil Chloroquine diphosphate in transfection Can plaquenil make psoriatic arthritis worse The Hydroxychloroquine Dosing Calculator calculates appropriate daily dose of hydroxychloroquine. Ideal Body Weight and Adjusted Body Weight; Since Plaquenil distributes in lean tissues and not fat, theoretically I would think they'd be at lower risk of toxicity, and I wonder if it may be better to use ideal body weight IBW instead for them. Per ideal body weight calculations, a man who weighs 135# or more and who is not obese should be on 400 mg a day. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. As one can see, the height that corresponds to an ideal body weight of 135 pounds varies across the formulas. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dosing ideal body weight Plaquenil Risk Calculators, NEW DOSE RECOMMENDATIONS FOR PLAQUENIL. - Lupus. Can plaquenil cause swollen lymph nodesPlaquenil testing protocolChloroquine and prescribing informationDrug interaction of chloroquineDifference between chloroquine and hydroxychloroquine SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. ACR Actual-weight hydroxychloroquine dosing works in SLE, up to a.. Ideal Body Weight for Calculating Hydroxychloroquine Dosage. Despite Plaquenil dosing recommendations, retinal toxicity.. A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after many years of treatment. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7. Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily. Comments -Each dose should be taken with a meal or a glass of milk. A total dose representing 25 mg of base per kg of body weight is administered in three days, as follows First dose 10 mg base per kg but not exceeding a single dose of 620 mg base. Second dose 5 mg base per kg but not exceeding a single dose of 310 mg base 6 hours after first dose.