One class of medications can lead to more severe vision loss in people with the wet form of the disease, and another class of drugs may have a beneficial effect. Fortunately, very few prescription drugs have any known detrimental effects for people with AMD. Chloroquine pretreatment Chloroquine resistant malaria map Plaquenil corneal deposits Aralen chloroquine phosphate Wet macular degeneration can result from progression of dry macular degeneration, left untreated, and affects about 10% of macular degeneration patients. If AMD is found first in one eye, the other eye follows the same progression. Hi this is my first post. I am on Plaquenil and have been only for 3-4 years now. I have noticed that my eyesight is getting worse. I went to my eye doctor 6 months ago and I was using cheater glasses at 150 strength and I complained about them not seeming strong enough which they weren't they should have been 200 strength. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. Doctors often put patients with certain potentially life-threatening cardiovascular conditions on this blood thinner. Warfarin (Coumadin®), which is an anticoagulant blood thinner, is one exception. Using plaquenil in end stage macular degeneration Pause the Plaquenil?, Has anyone experienced plaquenil toxicity with damage to eyes? - Chloroquine side effects pregnancyPlaquenil and thrombocytopeniaChloroquine help with payment for prescriptionsHydroxychloroquine warnings The other patient had Stargardt’s macular dystrophy, a rare hereditary disease that causes macular degeneration in adolescence. Both patients had end-stage disease with severe central vision loss. In the study researchers developed stem cells into cell types found within the eye and carefully injected the cells into specific locations within the eye. Stem cells safely used to treat macular degeneration - Health.. Methotrexate, Plaquenil or Sulfasalazine Azulfidine.. Plaqenil Role in Prevention of Age Related Macular Degeneration. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications. Aug 01, 2009 My mother was diagnosed with Plaquenil Toxicity in 2007 she first noticed changes in 2006, although being followed by her eye doctor they failed to notice this as Plaquenil TX until it was to late. After the medicine was Discontinued she continued to have more and more visual changes for the worse and still is declining in her vision. Medication Cautions in Macular Degeneration No summary can take the place of careful discussions with your health care professionals. Few patients consider visual symptoms as being related to their medicine.