Location: Thailand Purpose: The purpose of SEARCH 019 was to see how safely and effectively a combination of ART, vorinostat, hydroxychloroquine, and maraviroc controlled participants’ viral loads during a planned break from HIV medicines that followed the combination treatment. The researchers compared the combination treatment to ART alone. Plaquenil dosage based on weight Plaquenil to treat ankylosing spondylitis Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. People who are taking DMARDs are more prone to infection, especially in the first 6 months of treatment. Advise the person to avoid contact with people that have shingles or chickenpox. If they come in to contact with these people, they must seek urgent medical advice. Be aware of any adverse effects related to the DMARD. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Study Names: HCQ-01; NCT01067417 Phase: II Status: This study has been completed. SEARCH 026 was a substudy that evaluated the effect of vorinostat, hydroxychloroquine, and maraviroc on the brains and spinal cords of participants in SEARCH 019. Hydroxychloroquine during infection Hydroxychloroquine Oral Route Precautions - Mayo Clinic, DMARDs - NICE CKS Can you overdose on hydroxychloroquine SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Professional Patient Advice -. Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease COVID-19 - Full Text View. Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD. It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. New Zealand Data Sheet December 2018 Plaquenil – hydroxychloroquine sulfate plaquenil-ccdsv12-dsv11-18dec18 Page 7. In the treatment of rheumatoid arthritis, if objective improvement such as reduced joint swelling, increased mobility does not occur within six months, the drug should be discontinued.