Plaquenil retinal toxicity cumulative dose calculator

Discussion in 'Health Canada Drug Database' started by tanka7, 19-Mar-2020.

  1. s314 Guest

    Plaquenil retinal toxicity cumulative dose calculator

    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    The calculator can help guide clinicians toward a suggested weekly dosing schedule. It takes into account the patient’s weight and risk factors for Plaquenil retinopathy. With the weekly regimens, in some cases, the daily dose may exceed the 5mg/kg/day limit, but the weekly dose does not exceed 35mg/kg/week, the creators explain. A, Kaplan-Meier curves showing the cumulative risk of hydroxychloroquine retinal toxicity at 3 use levels. B, Smoothed hazard estimates showing yearly risk of toxic retinopathy at 3 use levels. C, Interaction of use and duration of use in the prevalence of retinal toxicity. Despite the fact that 1 there may be some gray areas in Plaquenil dosage calculations and 2 daily dosage is not the only risk factor, it is a risk factor that the eye care specialist can assess. Again, the calculations are not especially difficult, but I hope I can make them a little easier for the busy practitioner.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil retinal toxicity cumulative dose calculator

    Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS, Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA

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  4. Ocular Surgery News The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients.

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    The estimated risk of hydroxychloroquine retinopathy in patients on chronic hydroxychloroquine therapy ranges from 0.4% to 8.0%. 1 Toxicity is thought to be dependent on cumulative total dose. 3 Additional factors that can precipitate early toxicity are concomitant renal disease and use of tamoxifen. 3 Plaquenil is a drug that is stored in high concentrations throughout the body and is very slowly eliminated from the body. It is attracted to the retinal pigmented epithelium in the back of the eye the retina. Although rare, Plaquenil can cause significant toxicity to the eye with prolonged use. The relationship between daily and/or cumulative dose and toxicity is still unclear. check lean body weight with BMI calculator. Establish renal and liver function at baseline assessment. Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity a review review of mfERG ring ratios in Plaquenil toxicity.

  5. Dm!tro User

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  6. bester7 XenForo Moderator

    Retinal Physician - Hydroxychloroquine Maculopathy An. Advanced cases may demonstrate widespread retinal pigment epithelium atrophy, with a reduced visual field and decreased night vision. 3. Visual field. Parafoveal sensitivity loss is an early sign that may precede fundus changes. A computerized white-on-white 10-2 visual field test enables good resolution to test for macular sensitivity.

    Hydroxychloroquine-Induced Retinal Toxicity - American.