Chloroquine lung cancer

Discussion in 'Hydroxychloroquine Sulfate 200 Mg' started by SergVK, 20-Mar-2020.

  1. Lordius Well-Known Member

    Chloroquine lung cancer


    Alternatively, we suggest using this opportunity to take a little break from work and read some of the interesting articles below. Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks.

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    The most common type of lung cancer is adenocarcinoma ADC, comprising around 40% of all lung cancer cases. In spite of achievements in understanding the pathogenesis of this disease and the. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. Chloroquine CQ has been revealed to exhibit antitumor activity in several human tumors including lung cancer as mono‑ or add‑on therapy. The antitumor effect of CQ appears to depend on the tumor type, stage and genetic context.

    It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested.

    Chloroquine lung cancer

    Chloroquine inhibits cell growth and induces cell death in., Chloroquine in Cancer Therapy A Double-Edged Sword of.

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  6. Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice. OncoImmunology Vol. 6, No. 11, e1356151.

    • Chloroquine supplementation increases the cytotoxic effect of..
    • Chloroquine inhibits cell growth in human A549 lung cancer..
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    The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib. E Sunami, et al. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer. T Kometani, et al. Sensitivity to gefitinib Iressa, ZD1839 in non-small cell lung cancer cell lines. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. Chloroquine, a drug that has historically been used to treat malaria, has recently been combined with a new drug, Tarceva, which kills lung cancer cells. Tarceva only works for some patients, and the cancer almost always becomes resistant after prolonged exposure to the drug.

     
  7. webmast New Member

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