It typically happens in the evening or nighttime hours when you're sitting or lying down. Restless legs syndrome, also known as Willis-Ekbom disease, can begin at any age and generally worsens as you age. It can disrupt sleep, which interferes with daily activities. Symptoms of plaquenil eye problems Plaquenil fact sheet Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, Top 5 Drugs That Can Cause Pain Christina Lasich, MD Health Professional Aug 6, 2012 Imagine living in pain for years only to find out that one of your medications is the reason that you are in pain. Medications also help many people with symptoms as abnormal, unpleasant sensations in their legs or feet. They do, however, consistently describe the desire to move their legs. Sometimes, symptoms disappear for periods of time, then come back. Simple self-care steps and lifestyle changes may help relieve symptoms. The sensations, which generally occur within the limb rather than on the skin, are described as: usually don't describe the condition as a muscle cramp or numbness. Does plaquenil caus stiff legs Experiences taking Plaquenil for Fatigue and Muscle Pain? - Inspire, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Hydroxychloroquine flu vaccineGeneric vs brand plaquenilPlaquenil itchy skinPlaquenil price usAmsler grid and hydroxychloroquine maculopathy Common causes of muscle stiffness. Muscle stiffness typically occurs after exercise, hard physical work, or lifting weights. You may also feel stiffness after periods of inactivity, like when you get out of bed in the morning or get out of a chair after sitting for a long time. Muscle Stiffness Causes, Diagnosis, Treatment & More. Top 5 Drugs That Can Cause Pain - Causes - Chronic Pain. Joint Pain - Johns Hopkins Sjogrens Center. VICKABB responded I don't know for sure if it is the plaquenil or other meds but my rheumy seems to have my inflammation/stiffness under pretty good control. Been taking plaquenil and arava for about a year. Just rediced plaquenil from one tablet twice a day to one tablet once a day. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong.