Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Natural alternatives for plaquenil Cvs hidroxicloroquina plaquenil If you believe that your health is not improved but even worse then before, you should change therapy. At first, I had great relief from this drug, but later side effects developed mostly headaches bothered me. My eyes are painful, sometimes swollen and irritated, so I need to close them and take a break for some time. For the Consumer. Continuing ringing or buzzing or other unexplained noise in the ears. feeling of constant movement of self or surroundings. irritability. nausea. nervousness. nightmares. sensation of spinning. shakiness and unsteady walk. uncontrolled eye movements. unsteadiness, trembling, or. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Side effects of plaquenil on eyes Hydroxychloroquine - Wikipedia, Plaquenil Side Effects Common, Severe, Long Term - ChloroquinHydroxychloroquine sulfate usp 200 mg Serious side effects and their symptoms can include the following blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine-Induced Retinal Toxicity - American.. Protecting your eyesight when taking Plaquenil Lupus.. Side effect question for plaquenil/ eyes deleted_user 05/26/2011 I have been having some weird things happen but issues with my eyes is a very big part of my sjogrens so its hard to tell if its a side effect or just another symptom. Although rare, Plaquenil can cause significant toxicity to the eye with prolonged use. Also, Plaquenil may have various systemic side effects that are not related to the eyes. These too are rare and include nerve weakness, hallucinations, psoriasis and changes in hair color. The eye complications are the most serious and worrisome. Plaquenil is a drug used to treat Rheumatoid Arthritis and Systemic Lupus Erythematosis. It is a very good drug and gives many patients significant relief from their symptoms. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina.