Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil fda package insert Hydroxychloroquine sulphate tablets rheumatoid arthritis One hundred sixty-seven consecutive patients with acute chloroquine overdose admitted to our toxicology ICU. The mean amount ingested by history was 4.5 +2- 2.8 g. and 43 26% of 167 patients ingested 5 g. The mean blood chloroquine concentration on admission was 20.5 +/- 13.4 mumol/L. The only study in humans looking at severe chloroquine overdoses was done by Riou et al in 1988. 12 The criteria for severe chloroquine poisoning was an ingestion of 5 grams, which a retrospective study had determined to be an accurate predictor of a fatal outcome. They treated 11 prospective chloroquine overdose patients with immediate mechanical ventilation, epinephrine, and diazepam at 2 mg/kg over 30 minutes, then 1 to 2 mg/kg/day. Apr 02, 2019 Consider a 1 mmol/kg bolus of NaHCO3 prior to intubation to guard against acidemia from hypoventilation, which may worsen chloroquine toxicity. Some studies suggest that the use of thiopentone for induction is associated with cardiac arrest in cases of severe chloroquine toxicity. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Acute chloroquine poisoning Epidemiologic Notes and Reports Childhood Chloroquine., Treatment of hydroxychloroquine overdose - ScienceDirect What autoimmune diseases does does plaquenil treatIs plaquenil still availablePlaquenil blood plasma drops Quinine and chloroquine poisoning are characterized by severe cardiovascular toxicity resulting from sodium and potassium channel blockade, leading to hypotension, shock, arrhythmias and cardiac arrest. Quinine poisoning can cause irreversible visual loss. Quinine and chloroquine - ScienceDirect. Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum. Hydroxychloroquine-Induced Retinal Toxicity - American.. SummaryLarge doses of chloroquine can cause poisoning. Our aim was to determine the possible relation between the plasma potassium concentration on admission with the severity of acute chloroquine poisoning and to assess the mechanism of chloroquine-induced conducted a retrospective study of 191 consecutive cases. The main data included the occurrence of vomiting before. EUROPEAN JOURNAL OF PHARMACOLOGY 25 1974 210-215. NORTH-HOLLAND PUBLISHING COMPANY EFFECT OF HYPERTHERMIA ON ACUTE CHLOROQUINE TOXICITY IN RABBITS E. AYITEY-SMITH, G. L. BOYE, N. NICHANI and R. A. LEWIS Department of Pharmacology, University of Ghana Medical School, P. O. B. 4236, Accra, Ghana Received 3 July 1973 Accepted 22 October 1973 E. AYITEY-SMITH, G. L. BOYE, N. NICHANI and R. A. LEWIS. Case 2 was complicated by the absence of a helpful history and only the previous experience of acute pulmonary oedema associated with a story of a visit to a malarial district in the recent past raised the possibility of acute chloroquine poisoning.