He reported a history of tick bite and rash in 2002. The knee pain and other symptoms rapidly improved over the next two weeks. He received a short course of antibiotics at that time. After two weeks he reported that the antibiotics were causing nightmares and insomnia. Then one week later he complained of confusion and unsteadiness. Chloroquine inhibits autophagic flux by decreasing autophagosome lysosome fusion Chloroquine ibd Hydroxychloroquine usos Plaquenil vision report Lori, I'm not medically trained, but here's what I find on the internet for your consideration Plaquenil is a drug used to treat malaria and also in autoimmune conditions such as lupus and rheumatoid arthritis. The references I have found as to using it in Lyme treatment combine Plaquenil with another medication at the same time. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Mar 16, 2009 I was just prescribed plaquenil to treat the cyst form of lyme. The usage of the drug says it is to suppress the immune system in the treatment of lupus. Why would you want to do this if you have lyme. I thought steriods and drugs that suppress the immune system make treatment much slower. He continued to improve rapidly once more with a cessation of neurocognitive symptoms. When I saw him initially he complained of knee pain and swelling, fatigue, generalized arthralgia (joint pain), numbness and tingling and an irregular heart beat. I diagnosed a "brain Herx." I added Plaquenil back, as well as Welchol, presumptively to remove "neurotoxins." I also reduced the dose of Amoxicillin and Minocin. Plaquenil lyme disease treatment Treatment Lyme Disease CDC, Hydroxychloroquine Plaquenil Hydroxychloroquine and ibuprofen10 mg methotrexate weekly with plaquenil Treatment. Treatment of Lyme arthritis is based on several small, double-blind or randomized studies and observational studies summarized in Table 2. The efficacy of antibiotics was first demonstrated in a double-blind, placebo-controlled trial of IM benzathine penicillin, 2.4 million units weekly for 3 weeks versus placebo. Diagnosis and Treatment of Lyme Arthritis. Plaquenil questions -. Kills Babesia A Brief Guide - Treat Lyme. The three first-line oral antibiotics for Lyme disease include doxycycline Monodox, Doryx, Vibramycin, Oracea, amoxicillin Amoxil, and cefuroxime Ceftin, Zinacef. Ceftriaxone “Rocephin” administered intravenously is the preferred antibiotic for neurologic Lyme disease in the United States. There are a large number of options for treating Lyme disease and the coinfections associated with it. There’s the more traditional approach comprised of long-term antibiotics and some alternative approaches mostly centered around the use of herbs and supplements of course, some choose to do both at the same time. User Reviews for Hydroxychloroquine to treat Lyme Disease, Arthritis. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.