Why chloroquine has high volume of distribution

Discussion in 'Reliable Pharmacy' started by Gloria, 15-Mar-2020.

  1. zVerskiy New Member

    Why chloroquine has high volume of distribution


    In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment. Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula.

    Hydroxychloroquine plaquenil for malaria protection peru Sierra leone chloroquine

    Conversely, it may be decreased in dehydration. Acetylsalicylic acid has a low volume of distribution and is basically distributed in blood, whereas digoxin has a high volume of distribution and is distributed into intravascular space as well as fat and muscle. Hemodialysis removes only the toxins in the intravascular space. If the drug distributes into all body water the volume of distribution would increase to approximately = 0.57 l/kg If the drug readily diffuses into the body fat the volume of distribution may increase dramatically, an example is chloroquine which has a = 250-302 l/kg Drugs that have a volume of distribution 7 4 L or less are thought to be confined to the plasma, or liquid part of the blood. If the volume is between 7 4 and 15 7 L, the drug is thought to be distributed throughout the blood plasma and red blood cells. If the volume of distribution is larger than 42, the drug is thought to be distributed to all tissues in the body, especially the fatty tissue.

    As body composition changes with age, V But this is generally not what happens. Is not a physiologic value; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. The unit for Volume of Distribution is typically reported in liters.

    Why chloroquine has high volume of distribution

    Basic Concepts in Pharmacokinetics, Volume of distribution - Wikipedia

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    In contrast to quinine which has a relatively limited apparent volume of distribution approximately 2.51/kg in healthy adults and short elimination half-life 11 hours in healthy subjects, 16 hours in cerebral malaria, chloroquine has an enormous total apparent volume of distribution 100–10001/kg and a terminal elimination half-life of. Chloroquine was given in 300 mg single doses as an i.v. infusion, an oral solution and as tablets at intervals of at least 56 days to 11 healthy volunteers. Concentrations of chloroquine and its metabolite desethylchloroquine were measured in plasma, erythrocytes and urine using h.p.l.c. 2 Chloroquine was detectable in all plasma samples up. Volume of distribution has nothing to do with the actual volume of the body or its fluid compartments but rather involves the distribution of the drug within the body. For a drug that is highly tissue-bound, very little drug remains in the circulation; thus, plasma concentration is low and volume of distribution is high.

     
  7. Luna Guest

    This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Recommendations on Screening for Chloroquine and. Plaquenil oral Reviews and User Ratings Effectiveness. Eye screening for patients taking hydroxychloroquine Plaquenil
     
  8. AlexMudrii User

    Chloroquine Oral Uses, Side Effects, Interactions. Chloroquine belongs to a class of drugs known as antimalarials. The United States Centers for Disease Control provide updated guidelines and travel recommendations for the prevention and treatment.

    Chloroquine - Wikipedia